Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency. Summary. Scientists suggest there are links between deficiencies vitamin D, riboflavin, magnesium and migraine. They also indicate that supplementing these nutrients may ease symptoms. For

The role of vitamin D deficiency on migraine chronicity has not been clearly identified. The pathogenic mechanism of migraine chronicity presumes to be associated with a neurotransmitter imbalance and upregulation of inflammatory pathways in CNS resulting in central amplification of peripheral pain signals. [ 9]

^{The present findings show that supplementation with this vitamin in a dose of 1000-4000 IU/d could reduce the frequency of attacks in migraineurs. Conclusion: It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency.} suMY6.